ABSTRACT
Previous molecular genetic studies of laryngeal squamous cell carcinoma (SCC)have shown certain chromosomal regions with recurring alterations. But studies of sequential molecular alterations and genetic progression model of laryngeal SCC have not been clearly defined. To identify the chromosomal alterations associated with the carcinogenesis of laryngeal SCC, we analyzed genomic DNA from microdissected squamous metaplasia, squamous dysplasia, invasive SCC, and metastatic carcinoma samples from 22 laryngeal SCC patients for loss of heterozygosity (LOH) at microsatellite loci. Ten microsatellite markers on chromosome 3p, 8p, 9p, and 17p were used. LOH at 9p21 was observed in the all stages including squamous metaplasia, squamous dysplasia, invasive SCC and metastatic carcinoma. LOH at 17p13.1, 3p25 and 3p14.2 was observed from the squamous dysplasia, invasive SCC and metastatic carcinoma. LOH at 8p21.3-p22 was observed mainly from the invasive SCC and metastatic carcinoma. The results suggest that 9p21 in the early event, 17p13.1, 3p25 and 3p14.2 in the intermediate event and 8p21.3- p22 in the late event may be involved in the laryngeal carcinogenesis.
Subject(s)
Humans , Carcinoma, Squamous Cell/genetics , Chromosome Mapping , Chromosomes, Human, Pair 17 , Chromosomes, Human, Pair 3 , Chromosomes, Human, Pair 8 , Chromosomes, Human, Pair 9 , Disease Progression , Laryngeal Neoplasms/genetics , Larynx/pathology , Loss of Heterozygosity , Lymphatic Metastasis , Metaplasia/pathology , Microsatellite Repeats , Neoplasm MetastasisABSTRACT
Mucinous adenocarcinoma is a rare malignant neoplasm that occasionally occurs in gastrointestinal tract and mammary glands. It is characterized by large amounts of extracellular epithelial mucin that contains solitary epithelial cells, cords and nests. Mucinous adenocarcinoma of the major salivary glands is extremely rare, and only 10 cases have been reported. Recently, we experienced a case of mucinous adenocarcinoma of the parotid gland treated with total parotidectomy and postoperative radiotherapy. The patient has been free of disease for 2 years after treatment. So we report the case with a brief review of literature.
Subject(s)
Humans , Adenocarcinoma, Mucinous , Epithelial Cells , Gastrointestinal Tract , Mammary Glands, Human , Mucins , Parotid Gland , Radiotherapy , Salivary GlandsABSTRACT
Congenital esophageal stenosis is a extremely rare disease in childhood. We experienced one patient with a case of esophageal stenosis with esophageal solid food impaction. According to her history of dysphagia, cine esophagogram, pH-monitoring, and esophagoscopic findings, this esophageal stenosis was confirmed as congenital stenosis. We thus reported this case along with a relevant literature review.
Subject(s)
Humans , Constriction, Pathologic , Deglutition Disorders , Esophageal Stenosis , Foreign Bodies , Rare DiseasesABSTRACT
Malignant peripheral nerve sheath tumors arising de novo or from preexisting benign schwannoma or neurofibromatosis are highly aggressive tumors. Malignant peripheral nerve sheath tumor of the larynx is extremely rare neoplasm, for which accurate diagnosis is difficult and therapy is frequently delayed. Although wide surgical excision is the mainstay of treatment, radiation therapy plays a role in the control and treatment of locally recurrent disease and is useful for unresectable lesions. We present a case of malignant peripheral nerve sheath tumor of the larynx without definite evidences of von Recklinghausen's disease or preexisting benign peripheral nerve sheath tumor. This case is the third report of primary malignant peripheral nerve sheath tumor of the larynx according to the review of the literature.